@Article{info:doi/10.2196/60051,
author="Saslow, R. Laura
and Krinock, Jamie
and O'Brien, Alison
and Raymond, Kaitlyn
and Bayandorian, Hovig
and Moskowitz, T. Judith
and Daubenmier, Jennifer
and Oliveri, Antonino
and Marriott, J. Deanna
and Griauzde, H. Dina
and Speliotes, K. Elizabeth",
title="A Very Low--Carbohydrate Program in Adults With Metabolic Dysfunction--Associated Steatotic Liver Disease and Phospholipase Domain--Containing Protein 3 Risk Genotype: Pre-Post Intervention Study",
journal="JMIR Form Res",
year="2025",
month="Jan",
day="10",
volume="9",
pages="e60051",
keywords="metabolic dysfunction--associated steatotic liver disease",
keywords="ketogenic diet",
keywords="low carbohydrate",
keywords="adult",
keywords="genotype",
keywords="insulin",
keywords="insulin resistance",
keywords="metabolic dysfunction",
keywords="dietary pattern",
keywords="type 2 diabetes",
keywords="T2DM",
keywords="single-arm pilot trial",
keywords="liver function test",
keywords="genome",
keywords="non-alcoholic fatty liver disease",
abstract="Background: Insulin resistance and the G allele of rs738409 interact to create a greater risk of metabolic dysfunction--associated steatotic liver disease. Objective: This study aims to confirm that one promising way to reduce insulin resistance is by following a very low--carbohydrate (VLC) dietary pattern. Methods: Adults with rs738409-GG or -CG with liver steatosis and elevated liver function tests, were taught an ad libitum VLC diet, positive affect and mindful eating skills, goal setting, and self-monitoring and given feedback and coaching for 4 months. We measured liver steatosis, anthropometric, serum metabolic diet adherence, and quality of life measures. Results: In this small pilot trial, of the 11 participants enrolled, 9 (82\%) participants completed outcomes. All 11 participants viewed at least 1 session of the intervention, and 8 (73\%) participants viewed at least half of the sessions. Among the 9 participants who provided 4-month self-report information, intervention satisfaction was high (mean 6.22, 95\% CI 5.58-6.85), with 5 (56\%) participants rating the intervention the top score, and 4 (44\%) participants reporting they did not plan to stop following the VLC diet. Across participants with a 4-month hepatic liver fat percent measurement, the percent change in liver fat was ?33.17\% (95\% CI ?86.48 to 20.14), and in only the participants who were adherent to the eating pattern, the percent change in liver fat was ?53.12\% (95\% CI ?71.25 to ?34.99). Amongst participants with a 4-month hepatic liver fat percent measurement, 6 out of 8 (75\%) participants were considered responders, with a relative decline in liver fat ?30\%, and of the 9 participants with a 4-month body weight, 9 (100\%) participants lost ?5\% of their body weight. There were no serious adverse events. Conclusions: Results suggest the feasibility, acceptability, and preliminary efficacy of the VLC intervention in adults with higher genetic risk for metabolic dysfunction--associated steatotic liver disease, although there is a need for further studies given the small sample size and the high risk of substantial biases in this small pilot study. ",
doi="10.2196/60051",
url="https://formative.jmir.org/2025/1/e60051"
}


@Article{info:doi/10.2196/54158,
author="Adamou, Marios
and Jones, L. Sarah
and Kyriakidou, Niki
and Mooney, Andrew
and Pattani, Shriti
and Roycroft, Matthew",
title="Measuring Self-Reported Well-Being of Physicians Using the Well-Being Thermometer: Cohort Study",
journal="JMIR Form Res",
year="2025",
month="Jan",
day="9",
volume="9",
pages="e54158",
keywords="well-being",
keywords="health care professionals",
keywords="mental health",
keywords="well-being thermometer",
keywords="health care",
abstract="Background: Advancements in medical science have focused largely on patient care, often overlooking the well-being of health care professionals (HCPs). This oversight has consequences; not only are HCPs prone to mental and physical health challenges, but the quality of patient care may also endure as a result. Such concerns are also exacerbated by unprecedented crises like the COVID-19 pandemic. Compared to other sectors, HCPs report high incidence of stress, depression, and suicide, among other challenging factors that have a significant negative impact on their well-being. Objective: Given these substantial concerns, the development of a tool specifically designed to be used in clinical settings to measure the well-being of HCPs is essential. Methods: A United Kingdom--based cross-sectional pilot study was carried out to measure self-reported well-being in a cohort of 148 physicians, using the newly developed well-being thermometer. The aim of the tool is to allow respondents to develop an individual sense of ``well-being intelligence'' thus supporting HCPs to have better insight and control over their well-being and allow insights into how to manage it. The tool consists of 5 well-being domains---health, thoughts, emotions, spiritual, and social. Each domain can be measured individually or combined to produce an overall well-being score. Results: The tool demonstrated good internal consistency; the Cronbach $\alpha$ in this study was 0.84 for the total scale. Conclusions: Results from this cohort demonstrated that the well-being thermometer can be used to gather intelligence of staff well-being. This is a promising new tool that will assist HCPs to recognize their own well-being needs and allow health care organizations to facilitate change in policies and practices to reflect a better understanding of staff well-being. ",
doi="10.2196/54158",
url="https://formative.jmir.org/2025/1/e54158"
}