TY - JOUR AU - Trivedi, Ritu AU - Shaw, Tim AU - Sheahen, Brodie AU - Chow, Clara K AU - Laranjo, Liliana PY - 2025 DA - 2025/3/12 TI - Patient Perspectives on Conversational Artificial Intelligence for Atrial Fibrillation Self-Management: Qualitative Analysis JO - J Med Internet Res SP - e64325 VL - 27 KW - atrial fibrillation KW - conversational agents KW - qualitative research KW - self-management KW - digital health KW - patient perspective KW - conversational artificial intelligence KW - speech recognition AB - Background: Conversational artificial intelligence (AI) allows for engaging interactions, however, its acceptability, barriers, and enablers to support patients with atrial fibrillation (AF) are unknown. Objective: This work stems from the Coordinating Health care with AI–supported Technology for patients with AF (CHAT-AF) trial and aims to explore patient perspectives on receiving support from a conversational AI support program. Methods: Patients with AF recruited for a randomized controlled trial who received the intervention were approached for semistructured interviews using purposive sampling. The 6-month intervention consisted of fully automated conversational AI phone calls (with speech recognition and natural language processing) that assessed patient health and provided self-management support and education. Interviews were recorded, transcribed, and thematically analyzed. Results: We conducted 30 interviews (mean age 65.4, SD 11.9 years; 21/30, 70% male). Four themes were identified: (1) interaction with a voice-based conversational AI program (human-like interactions, restriction to prespecified responses, trustworthiness of hospital-delivered conversational AI); (2) engagement is influenced by the personalization of content, delivery mode, and frequency (tailoring to own health context, interest in novel information regarding health, overwhelmed with large volumes of information, flexibility provided by multichannel delivery); (3) improving access to AF care and information (continuity in support, enhancing access to health-related information); (4) empowering patients to better self-manage their AF (encouraging healthy habits through frequent reminders, reassurance from rhythm-monitoring devices). Conclusions: Although conversational AI was described as an engaging way to receive education and self-management support, improvements such as enhanced dialogue flexibility to allow for more naturally flowing conversations and tailoring to patient health context were also mentioned. Trial Registration: Australian New Zealand Clinical Trials Registry ACTRN12621000174886; https://tinyurl.com/3nn7tk72 International Registered Report Identifier (IRRID): RR2-10.2196/34470 SN - 1438-8871 UR - https://www.jmir.org/2025/1/e64325 UR - https://doi.org/10.2196/64325 DO - 10.2196/64325 ID - info:doi/10.2196/64325 ER -