TY  - JOUR
AU  - Holmen, Heidi
AU  - Holm, Are Martin
AU  - Falk, Ragnhild Sørum
AU  - Kilvær, Thomas Karsten
AU  - Ljosaa, Tone Marte
AU  - Ekholdt, Christopher
AU  - Fosse, Erik
PY  - 2025
DA  - 2025/4/28
TI  - A Digital Outpatient Service With a Mobile App for Tailored Care and Health Literacy in Adults With Long-Term Health Service Needs: Multicenter Nonrandomized Controlled Trial
JO  - J Med Internet Res
SP  - e60343
VL  - 27
KW  - outpatient
KW  - digital solution
KW  - mobile health
KW  - mHealth
KW  - remote monitoring
KW  - health literacy
KW  - self-monitoring
KW  - patient-reported outcome measures
KW  - cancer
KW  - complex pain
KW  - epilepsy
KW  - interstitial lung disease
AB  - Background: Patients with long-term health needs are often expected to actively participate in outpatient care, assuming that they have appropriate health literacy and digital health literacy. However, the association between participation in a digital outpatient service and health literacy remain unclear. Objective: This study aims to evaluate whether digital outpatient care for 6 months improved health literacy, health-related quality of life (HRQoL), digital/eHealth literacy, and the use of health care services compared with usual care. Methods: We conducted a multicenter nonrandomized trial with 1 intervention arm and 1 control arm. Patients aged ≥18 years receiving outpatient care in the pain, lung, neurology, or cancer departments at 2 Norwegian university hospitals were allocated in a 1:2 ratio, favoring the intervention arm. The intervention arm received digital outpatient care using tailored patient-reported outcome measures, self-monitoring, and chats for timely contact with the outpatient clinic. Patient responses were assessed by health care workers via a dashboard with a traffic light system to draw attention to the most urgent reports. The control arm received usual care. The data were collected at baseline and after 3 and 6 months. The primary outcome was the change in health literacy according to the Health Literacy Questionnaire domain understanding health information well enough to know what to do from baseline to 6 months. The mean difference in change between the 2 treatment arms was the effect measure. The secondary outcomes were additional domains from the Health Literacy Questionnaire, digital/eHealth literacy, HRQoL, acceptability of the digital intervention, and health service use. Results: Overall, 162 patients were recruited, 55 (34%) in the control arm and 107 (66%) in the intervention arm, with a 17.3% attrition rate after 6 months. There was no statistically significant difference in the primary outcome, “understanding health information well enough to know what to do,” between the arms at 6 months (mean difference –0.05, 95% CI –0.20 to 0.10; P=.53). After 3 months, the health literacy domains actively managing my own health (–0.15, 95% CI –0.30 to –0.00; P=.048) and understanding health information well enough to know what to do (–0.17, 95% CI –0.34 to –0.00; P=.03), as well as both physical (–3.29, 95% CI –5.62 to –0.96; P=.006) and mental HRQoL (–3.08, 95% CI –5.64 to –0.52; P=.02), improved in the digital outpatient intervention arm compared with the control arm. Conclusions: This study explored digital outpatient care. Although no statistical differences were observed in patients’ health literacy after 6 months, our data indicate an improvement in health literacy domains and HRQoL at 3 months. The participants reported high satisfaction with the digital outpatient care intervention, and our findings highlight the potential of digital interventions in outpatient care. Trial Registration: ClinicalTrials.gov NCT05068869; https://clinicaltrials.gov/ct2/show/NCT05068869 International Registered Report Identifier (IRRID): RR2-10.2196/46649 
SN  - 1438-8871
UR  - https://www.jmir.org/2025/1/e60343
UR  - https://doi.org/10.2196/60343
DO  - 10.2196/60343
ID  - info:doi/10.2196/60343
ER  -