TY  - JOUR
AU  - Jeanmougin, Pauline
AU  - Larramendy, Stéphanie
AU  - Fournier, Jean-Pascal
AU  - Gaultier, Aurélie
AU  - Rat, Cédric
PY  - 2024
DA  - 2024/12/18
TI  - Effect of a Feedback Visit and a Clinical Decision Support System Based on Antibiotic Prescription Audit in Primary Care: Multiarm Cluster-Randomized Controlled Trial
JO  - J Med Internet Res
SP  - e60535
VL  - 26
KW  - antibacterial agents
KW  - feedback
KW  - clinical decision support system
KW  - prescriptions
KW  - primary health care
KW  - clinical decision
KW  - antibiotic prescription
KW  - antimicrobial
KW  - antibiotic stewardship
KW  - interventions
KW  - health insurance
KW  - systematic antibiotic prescriptions
AB  - Background: While numerous antimicrobial stewardship programs aim to decrease inappropriate antibiotic prescriptions, evidence of their positive impact is needed to optimize future interventions. Objective: This study aimed to evaluate 2 multifaceted antibiotic stewardship interventions for inappropriate systemic antibiotic prescription in primary care. Methods: An open-label, cluster-randomized controlled trial of 2501 general practitioners (GPs) working in western France was conducted from July 2019 to January 2021. Two interventions were studied: the standard intervention, consisting of a visit by a health insurance representative who gave prescription feedback and provided a leaflet for treating cystitis and tonsillitis; and a clinical decision support system (CDSS)–based intervention, consisting of a visit with prescription feedback and a CDSS demonstration on antibiotic prescribing. The control group received no intervention. Data on systemic antibiotic dispensing was obtained from the National Health Insurance System (Système National d’Information Inter-Régimes de l’Assurance Maladie) database. The overall antibiotic volume dispensed per GP at 12 months was compared between arms using a 2-level hierarchical analysis of covariance adjusted for annual antibiotic prescription volume at baseline. Results: Overall, 2501 GPs were randomized (n=1099, 43.9% women). At 12 months, the mean volume of systemic antibiotics per GP decreased by 219.2 (SD 61.4; 95% CI −339.5 to −98.8; P<.001) defined daily doses in the CDSS-based visit group compared with the control group. The decrease in the mean volume of systemic antibiotics dispensed per GP was not significantly different between the standard visit group and the control group (−109.7, SD 62.4; 95% CI −232.0 to 12.5 defined daily doses; P=.08). Conclusions: A visit by a health insurance representative combining feedback and a CDSS demonstration resulted in a 4.4% (-219.2/4930) reduction in the total volume of systemic antibiotic prescriptions in 12 months. Trial Registration: ClinicalTrials.gov NCT04028830; https://clinicaltrials.gov/study/NCT04028830 
SN  - 1438-8871
UR  - https://www.jmir.org/2024/1/e60535
UR  - https://doi.org/10.2196/60535
UR  - http://www.ncbi.nlm.nih.gov/pubmed/39693139
DO  - 10.2196/60535
ID  - info:doi/10.2196/60535
ER  -