TY  - JOUR
AU  - Wu, Yong-Qiang
AU  - Long, Yi
AU  - Peng, Wei-Jie
AU  - Gong, Cheng
AU  - Liu, Yue-Quan
AU  - Peng, Xu-Miao
AU  - Zhong, Yan-Biao
AU  - Luo, Yun
AU  - Wang, Mao-Yuan
PY  - 2023
DA  - 2023/4/25
TI  - The Efficacy and Safety of Telerehabilitation for Fibromyalgia: Systematic Review and Meta-analysis of Randomized Controlled Trials
JO  - J Med Internet Res
SP  - e42090
VL  - 25
KW  - telerehabilitation
KW  - fibromyalgia
KW  - systematic review
KW  - meta-analysis
KW  - rehabilitation
KW  - chronic pain
KW  - pain
KW  - musculoskeletal
KW  - monitoring
KW  - intervention
KW  - consultation
KW  - education
KW  - efficacy
KW  - safety
AB  - Background: Fibromyalgia is a chronic pain syndrome characterized by persistent and widespread musculoskeletal pain. Telerehabilitation is a promising treatment for patients with fibromyalgia through long-term monitoring, intervention, supervision, consultation, and education. Objective: This study aimed to perform a comprehensive systematic review and meta-analysis of the efficacy and safety of telerehabilitation in patients with fibromyalgia. Methods: Randomized controlled trials (RCTs) related to fibromyalgia and telerehabilitation were systematically searched in the PubMed, PEDro, Cochrane Library, ScienceDirect, Ovid MEDLINE, Embase, and Web of Science databases from inception to November 13, 2022. Two independent researchers screened the literatures and evaluated the methodological quality using the Cochrane Risk of Bias Tool. The outcome measures included the Fibromyalgia Impact Questionnaire scale, pain intensity, depression, pain catastrophizing, quality of life (QoL), and adverse events. Pooled effect sizes were calculated by Stata SE 15.1; a fixed effects model was used when I2<50%, whereas a random effects model was used when I2≥50%. Results: A total of 14 RCTs with 1242 participants were included in this meta-analysis. The pooled results indicated that the telerehabilitation improved the Fibromyalgia Impact Questionnaire score (weighted mean difference –8.32, 95% CI –11.72 to –4.91; P<.001), pain intensity (standardized mean difference [SMD] –0.62, 95% CI –0.76 to –0.47; P<.001), depression levels (SMD –0.42, 95% CI –0.62 to –0.22; P<.001), pain catastrophizing (weighted mean difference –5.81, 95% CI –9.40 to –2.23; P=.001), and QoL (SMD 0.32, 95% CI 0.18 to 0.47; P<.001) in patients with fibromyalgia compared to control interventions. Only 1 RCT reported a mild adverse event of telerehabilitation; the other 13 RCTs did not mention this. Conclusions: Telerehabilitation can improve the symptoms and QoL of fibromyalgia. However, the safety of telerehabilitation remains uncertain due to the lack of sufficient evidence for the management of fibromyalgia. More rigorously designed trials are needed in the future to verify the safety and efficacy of telerehabilitation in fibromyalgia. Trial Registration: PROSPERO CRD42022338200; https://tinyurl.com/322keukv 
SN  - 1438-8871
UR  - https://www.jmir.org/2023/1/e42090
UR  - https://doi.org/10.2196/42090
UR  - http://www.ncbi.nlm.nih.gov/pubmed/37097721
DO  - 10.2196/42090
ID  - info:doi/10.2196/42090
ER  -