TY  - JOUR
AU  - Wang, Quan
AU  - Yang, Ke-Lu
AU  - Zhang, Zhen
AU  - Wang, Zhu
AU  - Li, Chen
AU  - Li, Lun
AU  - Tian, Jin-Hui
AU  - Ye, Ying-Jiang
AU  - Wang, Shan
AU  - Jiang, Ke-Wei
PY  - 2021
DA  - 2021/8/10
TI  - Characterization of Global Research Trends and Prospects on Single-Cell Sequencing Technology: Bibliometric Analysis
JO  - J Med Internet Res
SP  - e25789
VL  - 23
IS  - 8
KW  - single-cell sequencing
KW  - bibliometric analysis
KW  - cancer
KW  - cancer genomics
KW  - bioinformatics
KW  - cancer subtyping
KW  - tumor dissociation
KW  - tumor microenvironment
KW  - precision medicine
KW  - immunology
KW  - development trends
KW  - hotspots
KW  - research topics
KW  - Web of Science
KW  - CiteSpace
KW  - VOSviewer
KW  - network
AB  - Background: As single-cell sequencing technology has been gradually introduced, it is essential to characterize global collaboration networks and map development trends over the past 20 years. Objective: The aim of this paper was to illustrate collaboration in the field of single-cell sequencing methods and explore key topics and future directions. Methods: Bibliometric analyses were conducted with CiteSpace and VOSviewer software on publications prior to November 2019 from the Web of Science Core Collection about single-cell sequencing methods. Results: Ultimately, we identified 2489 records, which were published in 495 journals by 14,202 authors from 1970 institutes in 61 countries. There was a noticeable increase in publications in 2014. The United States and high-income countries in Europe contributed to most of the records included. Harvard University, Stanford University, Karolinska Institutes, Peking University, and the University of Washington were the biggest nodes in every cluster of the collaboration network, and SA Teichmann, JC Marioni, A Regev, and FC Tang were the top-producing authors. Keywords co-occurrence analysis suggested applications in immunology as a developing research trend. Conclusions: We concluded that the global collaboration network was unformed and that high-income countries contributed more to the rapidly growth of publications of single-cell sequencing technology. Furthermore, the application in immunology might be the next research hotspot and developmental direction. 
SN  - 1438-8871
UR  - https://www.jmir.org/2021/8/e25789
UR  - https://doi.org/10.2196/25789
UR  - http://www.ncbi.nlm.nih.gov/pubmed/34014832
DO  - 10.2196/25789
ID  - info:doi/10.2196/25789
ER  -