TY  - JOUR
AU  - Ritvo, Paul
AU  - Knyahnytska, Yuliya
AU  - Pirbaglou, Meysam
AU  - Wang, Wei
AU  - Tomlinson, George
AU  - Zhao, Haoyu
AU  - Linklater, Renee
AU  - Bai, Shari
AU  - Kirk, Megan
AU  - Katz, Joel
AU  - Harber, Lillian
AU  - Daskalakis, Zafiris
PY  - 2021
DA  - 2021/3/10
TI  - Online Mindfulness-Based Cognitive Behavioral Therapy Intervention for Youth With Major Depressive Disorders: Randomized Controlled Trial
JO  - J Med Internet Res
SP  - e24380
VL  - 23
IS  - 3
KW  - intervention study
KW  - telemedicine
KW  - electronic CBT
KW  - clinical trial
KW  - depression
KW  - cognitive behavioral therapy
KW  - CBT
KW  - online therapy
KW  - online intervention
KW  - youth
KW  - young adult
AB  - Background: Approximately 70% of mental health disorders appear prior to 25 years of age and can become chronic when ineffectively treated.  Individuals between 18 and 25 years old are significantly more likely to experience mental health disorders, substance dependencies, and suicidality. Treatment progress, capitalizing on the tendencies of youth to communicate online, can strategically address depressive disorders. Objective: We performed a randomized controlled trial (RCT) that compared online mindfulness-based cognitive behavioral therapy (CBT-M) combined with standard psychiatric care to standard psychiatric care alone in youth (18-30 years old) diagnosed with major depressive disorder. Methods: Forty-five participants were randomly assigned to CBT-M and standard care (n=22) or to standard psychiatric care alone (n=23). All participants were provided standard psychiatric care (ie, 1 session per month), while participants in the experimental group received an additional intervention consisting of the CBT-M online software program. Interaction with online workbooks was combined with navigation coaching delivered by phone and secure text messaging. Results: In a two-level linear mixed-effects model intention-to-treat analysis, significant between-group differences were found for the Beck Depression Inventory-II score (difference –8.54, P=.01), Quick Inventory of Depressive Symptoms score (difference –4.94, P=.001), Beck Anxiety Inventory score (difference –11.29, P<.001), and Brief Pain Inventory score (difference –1.99, P=.03), while marginal differences were found for the Five Facet Mindfulness Questionnaire–Nonjudging subscale (difference –2.68, P=.05). Conclusions: These results confirm that youth depression can be effectively treated with online CBT-M that can be delivered with less geographic restriction. Trial Registration: Clinical Trials.gov NCT03406052; https://www.clinicaltrials.gov/ct2/show/NCT03406052 
SN  - 1438-8871
UR  - https://www.jmir.org/2021/3/e24380
UR  - https://doi.org/10.2196/24380
UR  - http://www.ncbi.nlm.nih.gov/pubmed/33688840
DO  - 10.2196/24380
ID  - info:doi/10.2196/24380
ER  -