TY  - JOUR
AU  - Li, Guanjian
AU  - Li, Weiran
AU  - Song, Bing
AU  - Wang, Chao
AU  - Shen, Qunshan
AU  - Li, Bo
AU  - Tang, Dongdong
AU  - Xu, Chuan
AU  - Geng, Hao
AU  - Gao, Yang
AU  - Wang, Guanxiong
AU  - Wu, Huan
AU  - Zhang, Zhiguo
AU  - Xu, Xiaofeng
AU  - Zhou, Ping
AU  - Wei, Zhaolian
AU  - He, Xiaojin
AU  - Cao, Yunxia
PY  - 2021
DA  - 2021/2/25
TI  - Differences in the Gut Microbiome of Women With and Without Hypoactive Sexual Desire Disorder: Case Control Study
JO  - J Med Internet Res
SP  - e25342
VL  - 23
IS  - 2
KW  - gut microbiome
KW  - metabolome
KW  - sexual desire
KW  - online recruitment
KW  - biomarkers
AB  - Background: The gut microbiome is receiving considerable attention as a potentially modifiable risk factor and therapeutic target for numerous mental and neurological diseases. Objective: This study aimed to explore and assess the difference in the composition of gut microbes and fecal metabolites between women with hypoactive sexual desire disorder (HSDD) and healthy controls. Methods: We employed an online recruitment method to enroll “hard-to-reach” HSDD populations. After a stringent diagnostic and exclusion process based on DSM-IV criteria, fecal samples collected from 24 women with HSDD and 22 age-matched, healthy controls underwent microbiome analysis using 16S ribosomal RNA gene sequencing and metabolome analysis using untargeted liquid chromatography–mass spectrometry. Results: We found a decreased abundance of Ruminococcaceae and increased abundance of Bifidobacterium and Lactobacillus among women with HSDD. Fecal samples from women with HSDD showed significantly altered metabolic signatures compared with healthy controls. The abundance of Bifidobacterium, Lactobacillus, and several fecal metabolites correlated negatively with the sexual desire score, while the number of Ruminococcaceae correlated positively with the sexual desire score in all subjects. Conclusions: Our analysis of fecal samples from women with HSDD and healthy controls identified significantly different gut microbes and metabolic signatures. These preliminary findings could be useful for developing strategies to adjust the level of human sexual desire by modifying gut microbiota. Trial Registration: Chinese Clinical Trial Registry ChiCTR1800020321; http://www.chictr.org.cn/showproj.aspx?proj=34267 
SN  - 1438-8871
UR  - https://www.jmir.org/2021/2/e25342
UR  - https://doi.org/10.2196/25342
UR  - http://www.ncbi.nlm.nih.gov/pubmed/33629964
DO  - 10.2196/25342
ID  - info:doi/10.2196/25342
ER  -