TY  - JOUR
AU  - Frias, Mario
AU  - Moyano, Jose M
AU  - Rivero-Juarez, Antonio
AU  - Luna, Jose M
AU  - Camacho, Ángela
AU  - Fardoun, Habib M
AU  - Machuca, Isabel
AU  - Al-Twijri, Mohamed
AU  - Rivero, Antonio
AU  - Ventura, Sebastian
PY  - 2021
DA  - 2021/2/24
TI  - Classification Accuracy of Hepatitis C Virus Infection Outcome: Data Mining Approach
JO  - J Med Internet Res
SP  - e18766
VL  - 23
IS  - 2
KW  - HIV/HCV
KW  - data mining
KW  - PART
KW  - ensemble
KW  - classification accuracy
AB  - Background: The dataset from genes used to predict hepatitis C virus outcome was evaluated in a previous study using a conventional statistical methodology. Objective: The aim of this study was to reanalyze this same dataset using the data mining approach in order to find models that improve the classification accuracy of the genes studied. Methods: We built predictive models using different subsets of factors, selected according to their importance in predicting patient classification. We then evaluated each independent model and also a combination of them, leading to a better predictive model. Results: Our data mining approach identified genetic patterns that escaped detection using conventional statistics. More specifically, the partial decision trees and ensemble models increased the classification accuracy of hepatitis C virus outcome compared with conventional methods. Conclusions: Data mining can be used more extensively in biomedicine, facilitating knowledge building and management of human diseases. 
SN  - 1438-8871
UR  - https://www.jmir.org/2021/2/e18766
UR  - https://doi.org/10.2196/18766
UR  - http://www.ncbi.nlm.nih.gov/pubmed/33624609
DO  - 10.2196/18766
ID  - info:doi/10.2196/18766
ER  -