TY  - JOUR
AU  - Ariza-Garcia, Angelica
AU  - Lozano-Lozano, Mario
AU  - Galiano-Castillo, Noelia
AU  - Postigo-Martin, Paula
AU  - Arroyo-Morales, Manuel
AU  - Cantarero-Villanueva, Irene
PY  - 2019
DA  - 2019/07/24
TI  - A Web-Based Exercise System (e-CuidateChemo) to Counter the Side Effects of Chemotherapy in Patients With Breast Cancer: Randomized Controlled Trial
JO  - J Med Internet Res
SP  - e14418
VL  - 21
IS  - 7
KW  - breast cancer
KW  - chemotherapy
KW  - physical fitness
KW  - randomized control trial
KW  - telehealth
KW  - e-health
KW  - therapeutic exercise
AB  - Background: Breast cancer patients have to face a high-risk state during chemotherapy, which involves deterioration of their health including extensive physical deterioration. Face-to-face physical exercise programs have presented low adherence rates during medical treatment, and telehealth systems could improve these adherence rates. Objective: This study aimed to evaluate the effectiveness of a Web-based exercise program (e-CuidateChemo) to mitigate the side effects of chemotherapy on the physical being, anthropometric aspects, and body composition. Methods: A total of 68 patients diagnosed with breast cancer, who were undergoing chemotherapy, were enrolled. The patients were categorized into two groups: e-CuidateChemo (n=34) and controls (n=34). The e-CuidateChemo group participated in an adapted 8-week tailored exercise program through a Web-based system. A blinded, trained researcher assessed functional capacity, strength, anthropometric parameters, and body composition. The intervention effects were tested using analysis of covariance and Cohen d tests. Results: Functional capacity improved significantly in the e-CuidateChemo group compared to the control group (6-minute walk test: 62.07 [SD 130.09] m versus –26.34 [SD 82.21] m; 6-minute walk test % distance predicted: 10.81% [SD 22.69%] m versus –4.60% [SD 14.58%]; between-group effect: P=.015 for both). The intervention group also showed significantly improved secondary outcomes such as between-group effects for abdominal (24.93 [SD 26.83] s vs –18.59 [SD 38.69] s), back (12.45 [SD 10.20] kg vs 1.39 [10.72] kg), and lower body (–2.82 [SD 3.75] s vs 1.26 [SD 2.84] s) strength; all P<.001 compared to the control group. Conclusions: This paper showed that a Web-based exercise program was effective in reversing the detriment in functional capacity and strength due to chemotherapy. Trial Registration: ClinicalTrials.gov NCT02350582; https://clinicaltrials.gov/ct2/show/NCT02350582 
SN  - 1438-8871
UR  - http://www.jmir.org/2019/7/e14418/
UR  - https://doi.org/10.2196/14418
UR  - http://www.ncbi.nlm.nih.gov/pubmed/31342907
DO  - 10.2196/14418
ID  - info:doi/10.2196/14418
ER  -