TY  - JOUR
AU  - Mohr, David C
AU  - Duffecy, Jennifer
AU  - Jin, Ling
AU  - Ludman, Evette J
AU  - Lewis, Adam
AU  - Begale, Mark
AU  - McCarthy Jr, Martin
PY  - 2010
DA  - 2010/12/19
TI  - Multimodal E-Mental Health Treatment for Depression: A Feasibility Trial
JO  - J Med Internet Res
SP  - e48
VL  - 12
IS  - 5
KW  - Depression
KW  - Internet
KW  - feasibility
KW  - telephone
KW  - telemedicine
AB  - Background: Internet interventions for depression have shown less than optimal adherence. This study describes the feasibility trial of a multimodal e-mental health intervention designed to enhance adherence and outcomes for depression. The intervention required frequent brief log-ins for self-monitoring and feedback as well as email and brief telephone support guided by a theory-driven manualized protocol. Objective: The objective of this feasibility trial was to examine if our Internet intervention plus manualized telephone support program would result in increased adherence rates and improvement in depression outcomes. Methods: This was a single arm feasibility trial of a 7-week intervention. Results: Of the 21 patients enrolled, 2 (9.5%) dropped out of treatment. Patients logged in 23.2 ± 12.2 times over the 7 weeks. Significant reductions in depression were found on all measures, including the Patient Health Questionnaire depression scale (PHQ-8) (Cohen’s d = 1.96, P < .001), the Hamilton Rating Scale for Depression (d = 1.34, P < .001), and diagnosis of major depressive episode (P < .001). Conclusions: The attrition rate was far lower than seen either in Internet studies or trials of face-to-face interventions, and depression outcomes were substantial. These findings support the feasibility of providing a multimodal e-mental health treatment to patients with depression. Although it is premature to make any firm conclusions based on these data, they do support the initiation of a randomized controlled trial examining the independent and joint effects of Internet and telephone administered treatments for depression. 
SN  - 1438-8871
UR  - http://www.jmir.org/2010/5/e48/
UR  - https://doi.org/10.2196/jmir.1370
UR  - http://www.ncbi.nlm.nih.gov/pubmed/21169164
DO  - 10.2196/jmir.1370
ID  - info:doi/10.2196/jmir.1370
ER  -