%0 Journal Article
%@ 1438-8871
%I JMIR Publications
%V 27
%N 
%P e64687
%T Real-Time fMRI Neurofeedback Modulation of Dopaminergic Midbrain Activity in Young Adults With Elevated Internet Gaming Disorder Risk: Randomized Controlled Trial
%A Gu,Anqi
%A Chan,Cheng Lam
%A Xu,Xiaolei
%A Dexter,Joseph P
%A Becker,Benjamin
%A Zhao,Zhiying
%+ Centre for Cognitive and Brain Sciences, Institute of Collaborative Innovation, University of Macau, N21 Research building, Macau, 99078, China, 853 8822 9182, zhiyingzhao@um.edu.mo
%K real-time functional magnetic resonance imaging neurofeedback
%K internet gaming disorder
%K craving
%K reward processing
%K ventral tegmental area
%D 2025
%7 29.1.2025
%9 Research Letter
%J J Med Internet Res
%G English
%X This study provides preliminary evidence for real-time functional magnetic resonance imaging neurofeedback (rt-fMRI NF) as a potential intervention approach for internet gaming disorder (IGD). In a preregistered, randomized, single-blind trial, young individuals with elevated IGD risk were trained to downregulate gaming addiction–related brain activity. We show that, after 2 sessions of neurofeedback training, participants successfully downregulated their brain responses to gaming cues, suggesting the therapeutic potential of rt-fMRI NF for IGD (Trial Registration: ClinicalTrials.gov NCT06063642; https://clinicaltrials.gov/study/NCT06063642).
%R 10.2196/64687
%U https://www.jmir.org/2025/1/e64687
%U https://doi.org/10.2196/64687