%0 Journal Article %@ 1438-8871 %I JMIR Publications %V 27 %N %P e59217 %T Opportunities and Challenges in Using Electronic Health Record Systems to Study Postacute Sequelae of SARS-CoV-2 Infection: Insights From the NIH RECOVER Initiative %A Mandel,Hannah L %A Shah,Shruti N %A Bailey,L Charles %A Carton,Thomas %A Chen,Yu %A Esquenazi-Karonika,Shari %A Haendel,Melissa %A Hornig,Mady %A Kaushal,Rainu %A Oliveira,Carlos R %A Perlowski,Alice A %A Pfaff,Emily %A Rao,Suchitra %A Razzaghi,Hanieh %A Seibert,Elle %A Thomas,Gelise L %A Weiner,Mark G %A Thorpe,Lorna E %A Divers,Jasmin %A , %+ Department of Population Health, New York University Grossman School of Medicine, 180 Madison Avenue, New York, NY, 10016, United States, 1 732 314 1595, Hannah.Mandel@nyulangone.org %K COVID-19 %K SARS-CoV-2 %K Long COVID, post-acute COVID-19 syndrome %K electronic health records %K machine learning %K public health surveillance %K post-infection syndrome %K medical informatics %K electronic medical record %K electronic health record network %K electronic health record data %K clinical research network %K clinical data research network %K common data model %K digital health %K infection %K respiratory %K infectious %K epidemiological %K pandemic %D 2025 %7 5.3.2025 %9 Viewpoint %J J Med Internet Res %G English %X The benefits and challenges of electronic health records (EHRs) as data sources for clinical and epidemiologic research have been well described. However, several factors are important to consider when using EHR data to study novel, emerging, and multifaceted conditions such as postacute sequelae of SARS-CoV-2 infection or long COVID. In this article, we present opportunities and challenges of using EHR data to improve our understanding of long COVID, based on lessons learned from the National Institutes of Health (NIH)–funded RECOVER (REsearching COVID to Enhance Recovery) Initiative, and suggest steps to maximize the usefulness of EHR data when performing long COVID research. %M 40053748 %R 10.2196/59217 %U https://www.jmir.org/2025/1/e59217 %U https://doi.org/10.2196/59217 %U http://www.ncbi.nlm.nih.gov/pubmed/40053748