%0 Journal Article %@ 1438-8871 %I JMIR Publications %V 26 %N %P e60240 %T Perceptions of Illness Control, Coherence, and Self-Efficacy Following a Web-Based Lifestyle Program for Multiple Sclerosis: A Qualitative Analysis of Semistructured Interviews %A Davenport,Rebekah %A Bevens,William %A Neate,Sandra %A Jelinek,Pia %A Yu,Maggie %A Jelinek,George %A Reece,Jeanette %+ Department of Psychiatry, IN STEP Children’s Mental Health Research Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, United States, 1 858 534 7792, wbevens@health.ucsd.edu %K illness perceptions %K personal control perceptions %K illness coherence %K self-efficacy %K lifestyle modification %K disease management %K multiple sclerosis %K MS %K qualitative %K health behavior %K thematic analysis %D 2024 %7 29.11.2024 %9 Original Paper %J J Med Internet Res %G English %X Background: Evidence suggests that illness perceptions held by people living with multiple sclerosis (MS) impact affective distress and physical health outcomes. In a randomized controlled trial, we developed 2 MS Online Courses—the standard care course and the intervention course (IC). The IC was adapted from an evidence-based lifestyle program. Modifying lifestyle risk factors offers an opportunity to impact illness perceptions. Research on illness perceptions in people living with MS has focused predominately on quantitative methods. Objective: This study aimed to explore the experiences and health outcomes of randomized controlled trial participants, including individuals’ perceived changes in attitudes toward MS and their health (ie, illness perceptions). Methods: Qualitative responses provided by 38 participants (22 in the IC and 16 in the standard care course) were derived from semistructured interviews 1 month after completing the MS Online Course. The impact of course engagement and lifestyle modification on illness perceptions was explored using inductive thematic analysis. Results: Themes of changes in illness perceptions were most prominent in the IC arm. Qualitative responses from 22 people living with MS informed the development of three themes: “self-efficacy for disease management,” “personal control,” and “illness coherence.” Conclusions: Findings provide novel insights into the formation and modification of illness perceptions. Lifestyle modification may serve as a valuable adjunct to clinician-administered therapies, improving the sense of personal control over MS, illness coherence, and self-efficacy for disease management. Trial Registration: Australian New Zealand Clinical Trials Registry ACTRN12621001605886; https://tinyurl.com/2vyve9p9 International Registered Report Identifier (IRRID): RR2-10.1186/s12883-023-03298-0 %M 39612211 %R 10.2196/60240 %U https://www.jmir.org/2024/1/e60240 %U https://doi.org/10.2196/60240 %U http://www.ncbi.nlm.nih.gov/pubmed/39612211