%0 Journal Article
%@ 1438-8871
%I JMIR Publications
%V 25
%N 
%P e45362
%T The Overall Anxiety Severity and Impairment Scale as an Outcome Measure in Internet-Delivered Cognitive Behavioral Therapy for Anxiety Disorders: Observational Study
%A Karpov,Boris
%A Lipsanen,Jari Olavi
%A Ritola,Ville
%A Rosenström,Tom
%A Saarni,Suoma
%A Pihlaja,Satu
%A Stenberg,Jan-Henry
%A Laizane,Paula
%A Joffe,Grigori
%+ Department of Psychiatry, Helsinki University Hospital, Välskärinkatu 12, Helsinki, 00260, Finland, 358 401854948, boris.karpov@hus.fi
%K Overall Anxiety Severity and Impairment Scale
%K OASIS
%K internet-delivered cognitive behavioral therapy
%K iCBT
%K anxiety
%K social anxiety disorder
%K panic disorder
%K obsessive-compulsive disorder
%K OCD
%D 2023
%7 17.8.2023
%9 Original Paper
%J J Med Internet Res
%G English
%X Background: Internet-delivered cognitive behavioral therapy (iCBT) is effective in the treatment of anxiety disorders. iCBT clinical trials use relatively long and time-consuming disorder-specific rather than transdiagnostic anxiety measurements. Overall Anxiety Severity and Impairment Scale (OASIS) is a brief self-report scale that could offer a universal, easy-to-use anxiety measurement option in disorder-specific and transdiagnostic iCBT programs. Objective: We aimed to investigate relationships between OASIS and disorder-specific instruments in iCBT. We expected these relationships to be positive. Methods: We investigated patients in original nationwide iCBT programs for generalized anxiety disorder (GAD), obsessive-compulsive disorder, panic disorder, and social anxiety disorder, which were administered by Helsinki University Hospital, Finland. In each program, anxiety symptoms were measured using both disorder-specific scales (the 7-item Generalized Anxiety Disorder scale, Penn State Worry Questionnaire, revised Obsessive-Compulsive Inventory, Panic Disorder Severity Scale, and Social Phobia Inventory) and by OASIS. A general linear model for repeated measures (mixed models) and interaction analysis were used for investigating the changes and relationships in the mean scores of OASIS and disorder-specific scales from the first session to the last one. Results: The main effect of linear mixed models indicated a distinct positive association between OASIS and disorder-specific scale scores. Interaction analysis demonstrated relatively stable associations between OASIS and the revised Obsessive-Compulsive Inventory (F822.9=0.09; 95% CI 0.090-0.277; P=.32), and OASIS and the Panic Disorder Severity Scale (F596.6=–0.02; 95% CI –0.108 to –0.065; P=.63) from first the session to the last one, while the 7-item Generalized Anxiety Disorder scale (F4345.8=–0.06; 95% CI –0.109 to –0.017; P=.007), Penn State Worry Questionnaire (F4270.8=–0.52; 95% CI –0.620 to –0.437; P<.001), and Social Phobia Inventory (F862.1=–0.39; 95% CI –0.596 to –0.187; P<.001) interrelated with OASIS more strongly at the last session than at the first one. Conclusions: OASIS demonstrates clear and relatively stable associations with disorder-specific symptom measures. Thus, OASIS might serve as an outcome measurement instrument for disorder-specific and plausibly transdiagnostic iCBT programs for anxiety disorders in regular clinical practice. 
%M 37590055
%R 10.2196/45362
%U https://www.jmir.org/2023/1/e45362
%U https://doi.org/10.2196/45362
%U http://www.ncbi.nlm.nih.gov/pubmed/37590055