%0 Journal Article %@ 1438-8871 %I JMIR Publications %V 24 %N 1 %P e32368 %T Intensive Care Unit–Specific Virtual Reality for Critically Ill Patients With COVID-19: Multicenter Randomized Controlled Trial %A Vlake,Johan H %A van Bommel,Jasper %A Wils,Evert-Jan %A Bienvenu,Joe %A Hellemons,Merel E %A Korevaar,Tim IM %A Schut,Anna FC %A Labout,Joost AM %A Schreuder,Lois LH %A van Bavel,Marten P %A Gommers,Diederik %A van Genderen,Michel E %+ Department of Intensive Care, Erasmus MC, Dr Molewaterplein 40, Rotterdam, 3015 GD, Netherlands, 31 107039881, m.vangenderen@erasmusmc.nl %K SARS-CoV-2 %K intensive care %K post-intensive care syndrome %K virtual reality %K quality of life %K satisfaction %K COVID-19 %D 2022 %7 31.1.2022 %9 Original Paper %J J Med Internet Res %G English %X Background: Although psychological sequelae after intensive care unit (ICU) treatment are considered quite intrusive, robustly effective interventions to treat or prevent these long-term sequelae are lacking. Recently, it was demonstrated that ICU-specific virtual reality (ICU-VR) is a feasible and acceptable intervention with potential mental health benefits. However, its effect on mental health and ICU aftercare in COVID-19 ICU survivors is unknown. Objective: This study aimed to explore the effects of ICU-VR on mental health and on patients’ perceived quality of, satisfaction with, and rating of ICU aftercare among COVID-19 ICU survivors. Methods: This was a multicenter randomized controlled trial. Patients were randomized to either the ICU-VR (intervention) or the control group. All patients were invited to an COVID-19 post-ICU follow-up clinic 3 months after hospital discharge, during which patients in the intervention group received ICU-VR. One month and 3 months later (4 and 6 months after hospital discharge), mental health, quality of life, perceived quality, satisfaction with, and rating of ICU aftercare were scored using questionnaires. Results: Eighty-nine patients (median age 58 years; 63 males, 70%) were included. The prevalence and severity of psychological distress were limited throughout follow-up, and no differences in psychological distress or quality of life were observed between the groups. ICU-VR improved satisfaction with (mean score 8.7, SD 1.6 vs 7.6, SD 1.6 [ICU-VR vs control]; t64=–2.82, P=.006) and overall rating of ICU aftercare (mean overall rating of aftercare 8.9, SD 0.9 vs 7.8, SD 1.7 [ICU-VR vs control]; t64=–3.25; P=.002) compared to controls. ICU-VR added to the quality of ICU aftercare according to 81% of the patients, and all patients would recommend ICU-VR to other ICU survivors. Conclusions: ICU-VR is a feasible and acceptable innovative method to improve satisfaction with and rating of ICU aftercare and adds to its perceived quality. We observed a low prevalence of psychological distress after ICU treatment for COVID-19, and ICU-VR did not improve psychological recovery or quality of life. Future research is needed to confirm our results in other critical illness survivors to potentially facilitate ICU-VR’s widespread availability and application during follow-up. Trial Registration: Netherlands Trial Register NL8835; https://www.trialregister.nl/trial/8835 International Registered Report Identifier (IRRID): RR2-10.1186/s13063-021-05271-z %M 34978530 %R 10.2196/32368 %U https://www.jmir.org/2022/1/e32368 %U https://doi.org/10.2196/32368 %U http://www.ncbi.nlm.nih.gov/pubmed/34978530