%0 Journal Article
%@ 1438-8871
%I JMIR Publications
%V 23
%N 3
%P e20829
%T Evaluating a Hybrid Web-Based Training Program for Panic Disorder and Agoraphobia: Randomized Controlled Trial
%A Ebenfeld,Lara
%A Lehr,Dirk
%A Ebert,David Daniel
%A Kleine Stegemann,Stefan
%A Riper,Heleen
%A Funk,Burkhardt
%A Berking,Matthias
%+ Leuphana University, Universitätsallee 1, Lüneburg, 21335, Germany, 49 4131  677 1708, lara.ebenfeld@gmail.com
%K panic disorder
%K agoraphobia
%K treatment
%K internet
%K mobile phone
%K randomized controlled trial
%D 2021
%7 4.3.2021
%9 Original Paper
%J J Med Internet Res
%G English
%X Background: Previous studies provide evidence for the effectiveness of web-based interventions for panic disorder with and without agoraphobia. Smartphone-based technologies hold significant potential for further enhancing the accessibility and efficacy of such interventions. Objective: This randomized controlled trial aims to evaluate the efficacy of a guided, hybrid web-based training program based on cognitive behavioral therapy for adults with symptoms of panic disorder. Methods: Participants (N=92) with total scores in the Panic and Agoraphobia Scale ranging from 9 to 28 were recruited from the general population and allocated either to a hybrid intervention (GET.ON Panic) or to a wait-list control group. The primary outcome was the reduction in panic symptoms, as self-assessed using a web-based version of the Panic and Agoraphobia Scale. Results: Analysis of covariance-based intention-to-treat analyses revealed a significantly stronger decrease in panic symptoms posttreatment (F=9.77; P=.002; Cohen d=0.66; 95% CI 0.24-1.08) in the intervention group than in the wait-list control group. Comparisons between groups of the follow-up measures at 3 and 6 months yielded even stronger effects (3-month follow-up: F=17.40, P<.001, Cohen d=0.89, 95% CI 0.46-1.31; 6-month follow-up: F=14.63, P<.001, Cohen d=0.81, 95% CI 0.38-1.24). Conclusions: Hybrid web-based training programs may help reduce the symptoms of panic disorder and hence play an important role in improving health care for patients with this debilitating disorder. Trial Registration: German Clinical Trial Register DRKS00005223; https://tinyurl.com/f4zt5ran International Registered Report Identifier (IRRID): RR2-10.1186/1745-6215-15-427 
%M 33661121
%R 10.2196/20829
%U https://www.jmir.org/2021/3/e20829
%U https://doi.org/10.2196/20829
%U http://www.ncbi.nlm.nih.gov/pubmed/33661121