%0 Journal Article %@ 1438-8871 %I JMIR Publications %V 23 %N 12 %P e29127 %T Content and Dynamics of Websites Shared Over Vaccine-Related Tweets in COVID-19 Conversations: Computational Analysis %A Cruickshank,Iain %A Ginossar,Tamar %A Sulskis,Jason %A Zheleva,Elena %A Berger-Wolf,Tanya %+ Center for Computational Analysis of Social and Organizational Systems, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA, 15201, United States, 1 7192371515, icruicks@andrew.cmu.edu %K COVID-19 %K agenda setting %K antivaccination %K cross-platform %K data mining of social media %K misinformation %K social media %K Twitter %K vaccinations %K vaccine hesitancy %D 2021 %7 3.12.2021 %9 Original Paper %J J Med Internet Res %G English %X Background: The onset of the COVID-19 pandemic and the consequent “infodemic” increased concerns about Twitter’s role in advancing antivaccination messages, even before a vaccine became available to the public. New computational methods allow for analysis of cross-platform use by tracking links to websites shared over Twitter, which, in turn, can uncover some of the content and dynamics of information sources and agenda-setting processes. Such understanding can advance theory and efforts to reduce misinformation. Objective: Informed by agenda-setting theory, this study aimed to identify the content and temporal patterns of websites shared in vaccine-related tweets posted to COVID-19 conversations on Twitter between February and June 2020. Methods: We used triangulation of data analysis methods. Data mining consisted of the screening of around 5 million tweets posted to COVID-19 conversations to identify tweets that related to vaccination and including links to websites shared within these tweets. We further analyzed the content the 20 most-shared external websites using a mixed methods approach. Results: Of 841,896 vaccination-related tweets identified, 185,994 (22.1%) contained links to specific websites. A wide range of websites were shared, with the 20 most-tweeted websites constituting 14.5% (27,060/185,994) of the shared websites and typically being shared for only 2 to 3 days. Traditional media constituted the majority of these 20 websites, along with other social media and governmental sources. We identified markers of inauthentic propagation for some of these links. Conclusions: The topic of vaccination was prevalent in tweets about COVID-19 early in the pandemic. Sharing websites was a common communication strategy, and its “bursty” pattern and inauthentic propagation strategies pose challenges for health promotion efforts. Future studies should consider cross-platform use in dissemination of health information and in counteracting misinformation. %M 34665760 %R 10.2196/29127 %U https://www.jmir.org/2021/12/e29127 %U https://doi.org/10.2196/29127 %U http://www.ncbi.nlm.nih.gov/pubmed/34665760