%0 Journal Article %@ 1438-8871 %I JMIR Publications %V 22 %N 1 %P e14605 %T A Data-Driven Social Network Intervention for Improving Organ Donation Awareness Among Minorities: Analysis and Optimization of a Cross-Sectional Study %A Murphy,Michael Douglas %A Pinheiro,Diego %A Iyengar,Rahul %A Lim,Gene %A Menezes,Ronaldo %A Cadeiras,Martin %+ Department of Medicine, University of California, Los Angeles, CHS Building, 1st Fl, Los Angeles, CA, , United States, 1 6263406288, mikedmurph@gmail.com %K organ donation %K social media %K minority health %K community health education %D 2020 %7 14.1.2020 %9 Original Paper %J J Med Internet Res %G English %X Background: Increasing the number of organ donors may enhance organ transplantation, and past health interventions have shown the potential to generate both large-scale and sustainable changes, particularly among minorities. Objective: This study aimed to propose a conceptual data-driven framework that tracks digital markers of public organ donation awareness using Twitter and delivers an optimized social network intervention (SNI) to targeted audiences using Facebook. Methods: We monitored digital markers of organ donation awareness across the United States over a 1-year period using Twitter and examined their association with organ donation registration. We delivered this SNI on Facebook with and without optimized awareness content (ie, educational content with a weblink to an online donor registration website) to low-income Hispanics in Los Angeles over a 1-month period and measured the daily number of impressions (ie, exposure to information) and clicks (ie, engagement) among the target audience. Results: Digital markers of organ donation awareness on Twitter are associated with donation registration (beta=.0032; P<.001) such that 10 additional organ-related tweets are associated with a 3.20% (33,933/1,060,403) increase in the number of organ donor registrations at the city level. In addition, our SNI on Facebook effectively reached 1 million users, and the use of optimization significantly increased the rate of clicks per impression (beta=.0213; P<.004). Conclusions: Our framework can provide a real-time characterization of organ donation awareness while effectively delivering tailored interventions to minority communities. It can complement past approaches to create large-scale, sustainable interventions that are capable of raising awareness and effectively mitigate disparities in organ donation. %M 31934867 %R 10.2196/14605 %U https://www.jmir.org/2020/1/e14605 %U https://doi.org/10.2196/14605 %U http://www.ncbi.nlm.nih.gov/pubmed/31934867