%0 Journal Article
%@ 1438-8871
%I Gunther Eysenbach
%V 14
%N 1
%P e2
%T Is a Severe Clinical Profile an Effect Modifier in a Web-Based Depression Treatment for Adults With Type 1 or Type 2 Diabetes? Secondary Analyses From a Randomized Controlled Trial
%A van Bastelaar,Kim MP
%A Pouwer,François
%A Cuijpers,Pim
%A Riper,Heleen
%A Twisk,Jos WR
%A Snoek,Frank J
%+ Department of Medical Psychology, VU University Medical Centre, Van der Boechorststraat 7, Amsterdam, 1081 BT, Netherlands, 31 204448228, fj.snoek@vumc.nl
%K Diabetes mellitus, type 1
%K diabetes mellitus, type 2
%K depression
%K behavior therapy
%K cognitive therapy
%K depressive disorder
%K adults
%K psychology
%D 2012
%7 05.01.2012
%9 Original Paper
%J J Med Internet Res
%G English
%X Background: Depression and diabetes are two highly prevalent and co-occurring health problems. Web-based, diabetes-specific cognitive behavioral therapy (CBT) depression treatment is effective in diabetes patients, and has the potential to be cost effective and to have large reach. A remaining question is whether the effectiveness differs between patients with seriously impaired mental health and patients with less severe mental health problems. Objective: To test whether the effectiveness of an eight-lesson Web-based, diabetes-specific CBT for depression, with minimal therapist support, differs in patients with or without diagnosed major depressive disorder (MDD), diagnosed anxiety disorder, or elevated diabetes-specific emotional distress (DM-distress). Methods: We used data of 255 patients with diabetes with elevated depression scores, who were recruited via an open access website for participation in a randomized controlled trial, conducted in 2008–2009, comparing a diabetes-specific, Web-based, therapist-supported CBT with a 12-week waiting-list control group. We performed secondary analyses on these data to study whether MDD or anxiety disorder (measured using a telephone-administered diagnostic interview) and elevated DM-distress (online self-reported) are effect modifiers in the treatment of depressive symptoms (online self-reported) with Web-based diabetes-specific CBT. Results: MDD, anxiety disorder, and elevated DM-distress were not significant effect modifiers in the treatment of self-assessed depressive symptoms with Web-based diabetes-specific CBT. Conclusions: This Web-based diabetes-specific CBT depression treatment is suitable for use in patients with severe mental health problems and those with a less severe clinical profile. ClinicalTrial: International Standard Randomized Controlled Trial Number (ISRCTN): 24874457; http://www.controlled-trials.com/ISRCTN24874457 (Archived by WebCite at http://www.webcitation.org/63hwdviYr) 
%M 22262728
%R 10.2196/jmir.1657
%U http://www.jmir.org/2012/1/e2/
%U https://doi.org/10.2196/jmir.1657
%U http://www.ncbi.nlm.nih.gov/pubmed/22262728