%0 Journal Article
%@ 1438-8871
%I Gunther Eysenbach
%V 12
%N 5
%P e53
%T Cost-Utility and Cost-Effectiveness of Internet-Based Treatment for Adults With Depressive Symptoms: Randomized Trial
%A Warmerdam,Lisanne
%A Smit,Filip
%A van Straten,Annemieke
%A Riper,Heleen
%A Cuijpers,Pim
%+ Department of Clinical Psychology and EMGO Institute for Health and Care Research, VU University Medical Centre, Van der Boechorststraat 1, Amsterdam, 1081 BT, Netherlands, 31 20 5988959, eh.warmerdam@psy.vu.nl
%K Costs and cost analysis
%K cost-benefit analysis
%K depression
%K Internet
%K computer-assisted instruction
%K cognitive therapy
%K problem solving
%K randomized controlled trial
%D 2010
%7 19.12.2010
%9 Original Paper
%J J Med Internet Res
%G English
%X Background: The effectiveness of Internet-based treatments for depression has been demonstrated; their cost-effectiveness, however, has been less well researched. Objective: Evaluating the relative cost-utility and cost-effectiveness of (1) Internet-based cognitive behavioral therapy, (2) Internet-based problem-solving therapy, and (3) a waiting list for adults with depressive symptoms. Methods:  A total of 263 participants with clinically significant depressive symptoms were randomized to Internet-based cognitive behavioral therapy (n = 88), Internet-based problem-solving therapy (n = 88), and a waiting list (n = 87). End points were evaluated at the 12-week follow-up. Results: Cost-utility analysis showed that cognitive behavioral therapy and problem-solving therapy had a 52% and 61% probability respectively of being more acceptable than waiting when the willingness to pay is € 30,000 for one quality-adjusted life-year. When society is prepared to pay € 10,000 for a clinically significant change from depression, the probabilities of cognitive behavioral therapy and problem-solving therapy being more acceptable than waiting are 91% and 89%, respectively. Comparing both Internet-based treatments showed no clear preference for one or the other of the treatments. Conclusions: Both Internet-based treatments have a high probability of being cost-effective with a modest value placed on clinically significant change in depressive symptoms. Trial Registration: ISRCTN16823487; http://www.controlled-trials.com/ISRCTN16823487 (Archived by WebCite at http://www.webcitation.org/5u8slzhDE) 
%M 21169166
%R 10.2196/jmir.1436
%U http://www.jmir.org/2010/5/e53/
%U https://doi.org/10.2196/jmir.1436
%U http://www.ncbi.nlm.nih.gov/pubmed/21169166