%0 Journal Article
%@ 1438-8871
%I Gunther Eysenbach
%V 12
%N 5
%P e48
%T Multimodal E-Mental Health Treatment for Depression: A Feasibility Trial
%A Mohr,David C
%A Duffecy,Jennifer
%A Jin,Ling
%A Ludman,Evette J
%A Lewis,Adam
%A Begale,Mark
%A McCarthy Jr,Martin
%+ Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lakeshore Drive, Suite 1220, Chicago, 60611, USA, 1 312 503 1403, d-mohr@northwestern.edu
%K Depression
%K Internet
%K feasibility
%K telephone
%K telemedicine
%D 2010
%7 19.12.2010
%9 Original Paper
%J J Med Internet Res
%G English
%X Background: Internet interventions for depression have shown less than optimal adherence. This study describes the feasibility trial of a multimodal e-mental health intervention designed to enhance adherence and outcomes for depression. The intervention required frequent brief log-ins for self-monitoring and feedback as well as email and brief telephone support guided by a theory-driven manualized protocol. Objective: The objective of this feasibility trial was to examine if our Internet intervention plus manualized telephone support program would result in increased adherence rates and improvement in depression outcomes. Methods: This was a single arm feasibility trial of a 7-week intervention. Results: Of the 21 patients enrolled, 2 (9.5%) dropped out of treatment. Patients logged in 23.2 ± 12.2 times over the 7 weeks. Significant reductions in depression were found on all measures, including the Patient Health Questionnaire depression scale (PHQ-8) (Cohen’s d = 1.96, P < .001), the Hamilton Rating Scale for Depression (d = 1.34, P < .001), and diagnosis of major depressive episode (P < .001). Conclusions: The attrition rate was far lower than seen either in Internet studies or trials of face-to-face interventions, and depression outcomes were substantial. These findings support the feasibility of providing a multimodal e-mental health treatment to patients with depression. Although it is premature to make any firm conclusions based on these data, they do support the initiation of a randomized controlled trial examining the independent and joint effects of Internet and telephone administered treatments for depression. 
%M 21169164
%R 10.2196/jmir.1370
%U http://www.jmir.org/2010/5/e48/
%U https://doi.org/10.2196/jmir.1370
%U http://www.ncbi.nlm.nih.gov/pubmed/21169164