@Article{info:doi/10.2196/27370,
author="Nazarian, Scarlet
and Glover, Ben
and Ashrafian, Hutan
and Darzi, Ara
and Teare, Julian",
title="Diagnostic Accuracy of Artificial Intelligence and Computer-Aided Diagnosis for the Detection and Characterization of Colorectal Polyps: Systematic Review and Meta-analysis",
journal="J Med Internet Res",
year="2021",
month="Jul",
day="14",
volume="23",
number="7",
pages="e27370",
keywords="artificial intelligence; colonoscopy; computer-aided diagnosis; machine learning; polyp",
abstract="Background: Colonoscopy reduces the incidence of colorectal cancer (CRC) by allowing detection and resection of neoplastic polyps. Evidence shows that many small polyps are missed on a single colonoscopy. There has been a successful adoption of artificial intelligence (AI) technologies to tackle the issues around missed polyps and as tools to increase the adenoma detection rate (ADR). Objective: The aim of this review was to examine the diagnostic accuracy of AI-based technologies in assessing colorectal polyps. Methods: A comprehensive literature search was undertaken using the databases of Embase, MEDLINE, and the Cochrane Library. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed. Studies reporting the use of computer-aided diagnosis for polyp detection or characterization during colonoscopy were included. Independent proportions and their differences were calculated and pooled through DerSimonian and Laird random-effects modeling. Results: A total of 48 studies were included. The meta-analysis showed a significant increase in pooled polyp detection rate in patients with the use of AI for polyp detection during colonoscopy compared with patients who had standard colonoscopy (odds ratio [OR] 1.75, 95{\%} CI 1.56-1.96; P<.001). When comparing patients undergoing colonoscopy with the use of AI to those without, there was also a significant increase in ADR (OR 1.53, 95{\%} CI 1.32-1.77; P<.001). Conclusions: With the aid of machine learning, there is potential to improve ADR and, consequently, reduce the incidence of CRC. The current generation of AI-based systems demonstrate impressive accuracy for the detection and characterization of colorectal polyps. However, this is an evolving field and before its adoption into a clinical setting, AI systems must prove worthy to patients and clinicians. Trial Registration: PROSPERO International Prospective Register of Systematic Reviews CRD42020169786;  https://www.crd.york.ac.uk/prospero/display{\_}record.php?ID=CRD42020169786 ",
issn="1438-8871",
doi="10.2196/27370",
url="https://www.jmir.org/2021/7/e27370",
url="https://doi.org/10.2196/27370",
url="http://www.ncbi.nlm.nih.gov/pubmed/34259645"
}