@Article{info:doi/10.2196/jmir.1370,
author="Mohr, David C
and Duffecy, Jennifer
and Jin, Ling
and Ludman, Evette J
and Lewis, Adam
and Begale, Mark
and McCarthy Jr, Martin",
title="Multimodal E-Mental Health Treatment for Depression: A Feasibility Trial",
journal="J Med Internet Res",
year="2010",
month="Dec",
day="19",
volume="12",
number="5",
pages="e48",
keywords="Depression; Internet; feasibility; telephone; telemedicine",
abstract="Background: Internet interventions for depression have shown less than optimal adherence. This study describes the feasibility trial of a multimodal e-mental health intervention designed to enhance adherence and outcomes for depression. The intervention required frequent brief log-ins for self-monitoring and feedback as well as email and brief telephone support guided by a theory-driven manualized protocol. Objective: The objective of this feasibility trial was to examine if our Internet intervention plus manualized telephone support program would result in increased adherence rates and improvement in depression outcomes. Methods: This was a single arm feasibility trial of a 7-week intervention. Results: Of the 21 patients enrolled, 2 (9.5{\%}) dropped out of treatment. Patients logged in 23.2 {\textpm} 12.2 times over the 7 weeks. Significant reductions in depression were found on all measures, including the Patient Health Questionnaire depression scale (PHQ-8) (Cohen's d = 1.96, P < .001), the Hamilton Rating Scale for Depression (d = 1.34, P < .001), and diagnosis of major depressive episode (P < .001). Conclusions: The attrition rate was far lower than seen either in Internet studies or trials of face-to-face interventions, and depression outcomes were substantial. These findings support the feasibility of providing a multimodal e-mental health treatment to patients with depression. Although it is premature to make any firm conclusions based on these data, they do support the initiation of a randomized controlled trial examining the independent and joint effects of Internet and telephone administered treatments for depression. ",
issn="1438-8871",
doi="10.2196/jmir.1370",
url="http://www.jmir.org/2010/5/e48/",
url="https://doi.org/10.2196/jmir.1370",
url="http://www.ncbi.nlm.nih.gov/pubmed/21169164"
}